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We look forward to helping you answer your research questions!
Contact Us
info@sentinelstandards.com
Our Location
111 Riverbend Road
Athens, GA 30602
USA
Frequently Asked Questions
Are the standards available as individual structures, or are they pooled?
How do you confirm the purity and isotopic enrichment of each structure?
All compounds were synthesized using a panel of human glycosyltransferases. The advantage of human glycosyltransferases over their bacterial counterparts is that they do not have off-target activity, i.e., a monosaccharide is added to an acceptor at a single location. After a target has been prepared, it was purified using multi-dimensional chromatography, specifically C18 and HILIC. Incorporation of the six ¹³C atoms was confirmed via high-resolution mass (Bruker Solarix XR FTICR or Bruker Impact II Q-TOF) and ¹³C NMR. Glycoform purity was interrogated using LC-MS analysis of a procainamide labeled derivative.
I have a need for a standard not listed on your site. Can I submit it for consideration?
We are happy to look at any project and respond with its feasibility.
Do you sell standards in quantities larger than 10 μg?
Currently, all compounds are available in 10 μg aliquots. Please contact us if you have special requirements.
Does Sentinel collaborate with academic partners?
What custom synthesis services does Sentinel offer?
The team has wide-ranging experience in the field of carbohydrate synthesis. We have worked on projects related to N-glycans, O-glycans, human milk oligosaccharides, heparin, heparan sulfate, and glycopeptides. Our synthesized compounds have been used in mass spectrometry experiments, BLI screening, and Raman spectroscopy. Depending on the application, compounds can be prepared as native or isotopically enriched variants.
