Pioneering Precision in Glycomics
Isotopically labeled N-glycans for confident, reproducible analysis in proteomics, glycomics, and biopharma.
Sentinel Standards was established with the goal of providing valuable research products and services to scientsts operating in the fields of glycobiology, glycomics, and proteomics. The team comprises a group of research professionals with decades of experience in syntheszing carbohydrate targets using chemical and enzymatic strategies.
Our flagship product is a library of high-purity, isotopically labeled N-glycans designed to be employed as internal standards for glycomic and proteomic analyses. Library members are individually packaged in a high-recovery, 1.5 mL glass vial containing 10 μg of material for seamless incorporation into the end-user’s experimental workflow.
In addition to analytical reference material, we have an assortment of important glyco-epitopes and building blocks that can be used in a range of workflows such as binding assays and solid-phase-peptide synthesis.
Dr. Anthony Prudden is a synthetic carbohydrate chemist who earned his PhD under the supervision of Professor Geert-Jan Boons from the University of Georgia. His graduate work focused on the creation of the largest collection of synthetic human milk oligosaccharides. After graduating, Anthony pioneered methodologies for producing complex symmetric and asymmetric N-linked glycans of exceptional purity. His current synthetic efforts focus on the development of carbohydrate-based tools and reagents to advance research in glycomics and proteomics.
Our Process
Compound Synthesis
Each N-glycan target contains a uniformly labled 13C6 N-Acetylglucosamine and is custom synthesized using an enzymatic strategy to ensure absolute stereo- and regiocontrol.
Quality Control & Validation
Structural integrity of each compound is validated using a combination of NMR, high-resolution mass spectrometry, and reductive amination analysis. All data are available in a downloadable QC document.
Packaging & Labeling
Compounds are delivered in individually labeled, high-recovery glass vials containing 10 ug of solid material.
Distribution
Standards are distributed through our joint venture partner, Omicron Biochemicals, Inc., or you may contact us directly.
Application Areas:
- Academia
- Pharma
- Biotech
- Biomarker development
- Therapeutic QC
2024
Business line developed
Compound Purity
13C6 Enrichment
Can be used as an internal standard for absolute quantification (AQUA) analysis.
31
Validated N-Glycans Standards
Testimonials
It is with great pleasure that I recommend Anthony, a highly skilled and invaluable glycochemist who has contributed to the development of a scale-up protocol for one of our lead molecules. Beyond his profound knowledge, his hands-on approach and exceptional troubleshooting skills have been instrumental in supporting our Contract Research Organization (CRO) throughout the development process. Anthony’s contributions have been a significant asset to our company, and I am confident he would bring the same level of dedication, expertise, and problem-solving ability to any future endeavor.
Anitha Krishnan PhD
Executive Director, Research,
Aviceda Therapeutics, Inc
Anthony produced an incredible library of unique glycans we could use for our project on antibody and RNA glyco-sequencing. His glycans were of high-purity, with all the variety we needed for our development. He was also very responsive to any questions we had. We feel fortunate to have collaborated with him.
Jennifer Dionne PhD
Professor, Material Science and Engineering
Stanford University
Ready to integrate high-quality glycans into your research?
Whether you’re looking to explore available compounds or discuss a custom synthesis project – we’re happy to help!
