GL-3459
Compound name(s): Sialyl Lewis X, Sialyl-Lewis X, SLeX bearing an aminopentanol anomeric linker.
Anomeric linker: 5-amino-1-pentanol
Chemical formula: C36H62N3O23Na
Physical state of bulk product: White, fluffy solid
Molar mass: 927.88
Compound information: Sialyl Lewis X is an important glyco-epitope comprising a terminal α2,3-sialic acid and internal α1,3-fucose linkage. This tetrasaccharide is a reported ligand for the selectin family (E-, P-, and L-selectin), mediating the initial rolling and adhesion of leukocytes on activated endothelium during inflammation. The same epitope is recognized as a tumor-associated carbohydrate antigen, with elevated surface expression linked to selectin-mediated metastasis in several cancers. With the aminopentanol linker, this compound can be conjugated to surfaces or carrier proteins to study selectin-carbohydrate binding kinetics or to support selectin-inhibitor discovery efforts.
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QC report for GL-3459
References (links open in a new tab):
1. C Foxall, SR Watson, D Dowbenko, C Fennie, LA Lasky, M Kiso, A Hasegawa, D Asa, BK Brandley; The three members of the selectin receptor family recognize a common carbohydrate epitope, the sialyl Lewis(x) oligosaccharide. J Cell Biol 1992, 117 (4), 895–902.
2. Kiyoyasu Fukushima, Masaki Hirota, Paul I. Terasaki, Akemi Wakisaka, Hiroyuki Togashi, David Chia, Naofuml Suyama, Yasuo Fukushi, Edward Nudelman, Sen-Itiroh Hakomori; Characterization of Sialosylated Lewisx as a New Tumor-associated Antigen. Cancer Res 1984, 44 (11), 5279–5285.